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Nat Rev Mol Cell Biol. 2003 Jul;4(7):552-65.

Regulation of cell death: the calcium-apoptosis link.

Author information

1
Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden. Sten.Orrenius@imm.ki.se

Abstract

To live or to die? This crucial question eloquently reflects the dual role of Ca2+ in living organisms--survival factor or ruthless killer. It has long been known that Ca2+ signals govern a host of vital cell functions and so are necessary for cell survival. However, more recently it has become clear that cellular Ca2+ overload, or perturbation of intracellular Ca2+ compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell death.

PMID:
12838338
DOI:
10.1038/nrm1150
[Indexed for MEDLINE]

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