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Nat Rev Mol Cell Biol. 2003 Jul;4(7):517-29.

Calcium signalling: dynamics, homeostasis and remodelling.

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1
Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK. michael.berridge@bbsrc.ac.uk

Abstract

Ca2+ is a highly versatile intracellular signal that operates over a wide temporal range to regulate many different cellular processes. An extensive Ca2+-signalling toolkit is used to assemble signalling systems with very different spatial and temporal dynamics. Rapid highly localized Ca2+ spikes regulate fast responses, whereas slower responses are controlled by repetitive global Ca2+ transients or intracellular Ca2+ waves. Ca2+ has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.

PMID:
12838335
DOI:
10.1038/nrm1155
[Indexed for MEDLINE]
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