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Cell. 2003 Jun 27;113(7):825-8.

The human Y chromosome: rumors of its death have been greatly exaggerated.

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  • 1Stowers Institute for Medical Research, Kansas City, MO 64110, USA.


Recent papers by David Page and his collaborators present an intriguing new face to the human Y chromosome, including eight massive palindromic arrays, most of which contain multi-copy pairs of testis-specific genes. Sequence pairs within the arms of these palindromic sequences retain a high degree of similarity, suggesting that intrachromosomal gene conversion is frequent, perhaps providing a means of maintaining the integrity of individual members of the array.

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