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Cell. 2003 Jun 27;113(7):821-3.

Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants-or both?

Author information

1
Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. rohynes@mit.edu

Abstract

Metastasis is a rare event. Does it arise from rare, variant, highly metastatic cells or does a primary tumor progress to a premalignant state from which metastases arise stochastically without further changes in gene expression? Arguments and evidence have been adduced to support either position. A paper in this month's Cancer Cell and other arguments instead suggest models combining features of both.

PMID:
12837240
DOI:
10.1016/s0092-8674(03)00468-9
[Indexed for MEDLINE]
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