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J Exp Med. 2003 Jul 7;198(1):123-32. Epub 2003 Jun 30.

Restricted clonal expression of IL-2 by naive T cells reflects differential dynamic interactions with dendritic cells.

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1
Department of Pathology, University of Alabama at Birmingham, AL 35294, USA.

Abstract

Limited frequencies of T cells express IL-2 in primary antigenic responses, despite activation marker expression and proliferation by most clonal members. To define the basis for restricted IL-2 expression, a videomicroscopic system and IL-2 reporter transgenic model were used to characterize dendritic cell (DC)-T cell interactions. T cells destined to produce IL-2 required prolonged interactions with DCs, whereas most T cells established only transient interactions with DCs and were activated, but did not express IL-2. Extended conjugation of T cells with DCs was not always sufficient to initiate IL-2 expression. Thus, there is intrinsic variability in clonal T cell populations that restricts IL-2 commitment, and prolonged engagement with mature DCs is necessary, but not sufficient, for IL-2 gene transcription.

PMID:
12835480
PMCID:
PMC2196090
DOI:
10.1084/jem.20022230
[Indexed for MEDLINE]
Free PMC Article
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