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Biosci Biotechnol Biochem. 2003 May;67(5):1140-3.

Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract.

Author information

1
Research and Development Division, Kikkoman Corporation, 399 Noda, Noda, Chiba 278-0037, Japan. asano@mail.kikkoman.co.jp

Abstract

To confirm the absorption of proanthocyanidin (PA) into the human body, four healthy adults were administered 2.0 g of PA-rich grape seed extract (GSE). Blood were drawn before intake and 2 h after intake. Through the enzymatic treatment of sulfatase and beta-glucuronidase, blood samples were analyzed by HPLC coupled with mass-spectrometry (LC/MS). Procyanidin B1 [epicatechin-(4beta-->8)-catechin] was detected in human serum 2 h after intake. Its concentration was 10.6 +/- 2.5 nmol/l.

PMID:
12834296
DOI:
10.1271/bbb.67.1140
[Indexed for MEDLINE]
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