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Curr Opin Investig Drugs. 2003 May;4(5):556-65.

Anti-inflammatory activity of neutrophil elastase inhibitors.

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Unité de recherche, Hôpital Laval, Institut universitaire de cardiologie et de pneumologie, l'Université Laval, 2725 chemin Sainte-Foy, Sainte-Foy, G1V 4G5, Canada.


Neutrophil elastase is a protease that is involved in the tissue destruction and inflammation that characterize numerous diseases, including hereditary emphysema, chronic obstructive pulmonary disease, cystic fibrosis, adult respiratory distress syndrome, ischemic-reperfusion injury and rheumatoid arthritis. Thus, elastase has been the object of extensive research to develop potent inhibitors that target its destructive and pro-inflammatory action. This review focuses on the anti-inflammatory activity of inhibitors that are currently, or were until recently in development, including purified or recombinantly produced endogenous inhibitors, genetically modified recombinant protein inhibitors and synthetic small-molecule inhibitors.

[Indexed for MEDLINE]

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