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Curr Opin Microbiol. 2003 Jun;6(3):229-35.

Biodesulfurization of fossil fuels.

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Diversa Corporation, 4955 Director's Place, San Diego, CA 92121, USA.


Biotechnological techniques enabling the specific removal of sulfur from fossil fuels have been developed. In the past three years there have been important advances in the elucidation of the mechanisms of biodesulfurization; some of the most significant relate to the role of a flavin reductase, DszD, in the enzymology of desulfurization, and to the use of new tools that enable enzyme enhancement via DNA manipulation to influence both the rate and the substrate range of Dsz. Also, a clearer understanding of the unique desulfinase step in the pathway has begun to emerge.

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