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Curr Opin Struct Biol. 2003 Jun;13(3):377-82.

Computational methods of analysis of protein-protein interactions.

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  • 1Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, Departments of Chemistry & Biochemistry and Biological Chemistry, Molecular Biology Institute, Box 951570, UCLA, Los Angeles, CA 90095-1570, USA.


Computational methods play an important role at all stages of the process of determining protein-protein interactions. They are used to predict potential interactions, to validate the results of high-throughput interaction screens and to analyze the protein networks inferred from interaction databases.

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