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Curr Opin Struct Biol. 2003 Jun;13(3):284-99.

Recognition of the DNA minor groove by pyrrole-imidazole polyamides.

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1
Division of Chemistry and Chemical Engineering, and Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA. dervan@cco.caltech.edu

Abstract

Many diseases, such as cancer, are related to aberrant gene expression. Regulating transcription by chemical methods could be important in human medicine. Minor groove-binding polyamides offer one chemical approach to DNA recognition.

PMID:
12831879
[Indexed for MEDLINE]
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