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Clin Infect Dis. 2003 Jul 1;37(1):137-40. Epub 2003 Jun 24.

Interleukin-12 receptor beta1 deficiency presenting as recurrent Salmonella infection.

Author information

1
Pediatric Department, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel 84101.

Abstract

We describe a child with interleukin-12 receptor beta1 (IL-12Rbeta1) deficiency caused by a homozygous IL12RB1 large deletion who presented at the age of 1 year with recurrent, often asymptomatic episodes of bacteremia caused by group D Salmonella species. No mycobacterial disease or other unusual infection was present. The episodes of salmonellosis were caused by an identical serovar during a period of 18 months. This is the first case of inherited IL-12Rbeta1 deficiency diagnosed after isolated, recurrent salmonellosis.

PMID:
12830418
DOI:
10.1086/375229
[Indexed for MEDLINE]

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