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Diabetes. 2003 Jul;52(7):1591-4.

Magnetic resonance-defined periportal steatosis following intraportal islet transplantation: a functional footprint of islet graft survival?

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Department of Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA.


There is growing interest in more widespread application of isolated islet transplantation for the treatment of type 1 diabetes; however, the sequelae of long-term islet residence within the liver are unknown. We report herein a consequence of intraportal islet transplantation, specifically the development of periportal hepatic steatosis apparently induced by the local secretion of insulin within the liver.

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