Format

Send to

Choose Destination
FEBS Lett. 2003 Jul 3;546(1):108-12.

Unravelling the activation mechanisms of protein kinase B/Akt.

Author information

1
Ontario Cancer Institute, 610 University Avenue, Toronto, ON, Canada M5G 2M9.

Abstract

Over the past decade, protein kinase B (PKB, also termed Akt) has emerged as an important signaling mediator between extracellular cues and modulation of gene expression, metabolism, and cell survival. The enzyme is tightly controlled and consequences of its deregulation include loss of growth control and oncogenesis. Recent work has better characterized the mechanism of PKB activation, including upstream regulators and secondary binding partners. This minireview refreshes some old concepts with new twists and highlights current outstanding questions.

PMID:
12829245
DOI:
10.1016/s0014-5793(03)00562-3
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center