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FEBS Lett. 2003 Jul 3;546(1):103-7.

Search for new cyclic AMP-binding proteins.

Author information

1
IRIBHM, Faculty of Medicine, Free University of Brussels, 808 Route de Lennik, 1070 Brussels, Belgium. sdremier@ulb.ac.be

Abstract

Today, there is evidence that the cAMP-dependent kinases (PKA) are not the only intracellular receptors involved in intracellular cAMP signalling in eukaryotes. Other cAMP-binding proteins have been recently identified, including some cyclic nucleotide-gated channels and Epac (exchange protein directly activated by cAMP) proteins. All these proteins bind cAMP through conserved cyclic nucleotide monophosphate-binding domains. However, all putative cAMP-binding proteins having such domains, as revealed by computer analysis, do not necessarily bind cAMP, indicating that their presence is not a sufficient criteria to predict cAMP-binding property for a protein.

PMID:
12829244
[Indexed for MEDLINE]
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