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FEBS Lett. 2003 Jul 3;546(1):65-72.

The 'magic tail' of G protein-coupled receptors: an anchorage for functional protein networks.

Author information

1
Laboratoire de Génomique Fonctionnelle, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France. joel.bockaert@ccipe.cnrs.fr

Abstract

All cell types express a great variety of G protein-coupled receptors (GPCRs) that are coupled to only a limited set of G proteins. This disposition favors cross-talk between transduction pathways. However, GPCRs are organized into functional units. They promote specificity and thus avoid unsuitable cross-talk. New methodologies (mostly yeast two-hybrid screens and proteomics) have been used to discover more than 50 GPCR-associated proteins that are involved in building these units. In addition, these protein networks participate in the trafficking, targeting, signaling, fine-tuning and allosteric regulation of GPCRs. To date, proteins that interact with the GPCR C-terminus are the most abundant and are the focus of this review.

PMID:
12829238
DOI:
10.1016/s0014-5793(03)00453-8
[Indexed for MEDLINE]
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