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Am J Hematol. 2003 Jul;73(3):211-2.

Developing human erythroid cells grown in transferrin-free medium utilize iron originating from extracellular ferritin.

Author information

1
Department of Human Nutrition and Metabolism, Faculty of Medicine, The Hebrew University, Jerusalem, Israel.

Abstract

In addition to transferrin, ferritin can also function as a source of iron for heme synthesis (Gelvin D, et al. Blood 1996;88:3200-3207; Meyron-Holtz EG, et al. Blood 1999;94:3205-3211). In the present study we investigate the effect of external ferritin on the proliferation and hemoglobinization of human erythroid precursors grown in transferrin-free cultures.

PMID:
12827660
DOI:
10.1002/ajh.10355
[Indexed for MEDLINE]
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