Format

Send to

Choose Destination
J Mol Med (Berl). 2003 Jul;81(7):392-403. Epub 2003 Jun 25.

Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling.

Author information

1
Department of Molecular and Cellular Biology, Arizona Cancer Center, University of Arizona, Tucson, USA.

Abstract

It is becoming clear that converging pathways coordinate early heart valve development and remodeling into functional valve leaflets. The integration of these pathways begins with macro and molecular interactions outside the cell in the extracellular matrix separating the myocardial and endocardial tissue components of the rudimentary heart. Such interactions regulate events at the cell surface through receptors, proteases, and other membrane molecules which in turn transduce signals into the cell. These signals trigger intracellular cascades that transduce cellular responses through both transcription factor and cofactor activation mediating gene induction or suppression. Chamber septation and valve formation occur from these coordinated molecular events within the endocardial cushions to sustain unidirectional blood flow and embryo viability. This review discusses the emerging connection between extracellular matrix and growth factor receptor signaling during endocardial cushion morphogenesis by highlighting the extracellular component, hyaluronan, and erbB receptor functions during early valve development.

PMID:
12827270
DOI:
10.1007/s00109-003-0456-5
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center