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Neuropsychopharmacology. 2003 Jul;28 Suppl 1:S27-34.

Obsessive-compulsive disorder: development of demand-controlled deep brain stimulation with methods from stochastic phase resetting.

Author information

1
Institute of Medicine, Research Center Jülich, 52425 Jülich, Germany. P.Tass@fz-juelich.de

Abstract

Synchronization of neuronal firing is a hallmark of several neurological diseases. Recently, stimulation techniques have been developed which make it possible to desynchronize oscillatory neuronal activity in a mild and effective way, without suppressing the neurons' firing. As yet, these techniques are being used to establish demand-controlled deep brain stimulation (DBS) techniques for the therapy of movement disorders like severe Parkinson's disease or essential tremor. We here present a first conceptualization suggesting that the nucleus accumbens is a promising target for the standard, that is, permanent high-frequency, DBS in patients with severe and chronic obsessive-compulsive disorder (OCD). In addition, we explain how demand-controlled DBS techniques may be applied to the therapy of OCD in those cases that are refractory to behavioral therapies and pharmacological treatment.

PMID:
12827141
DOI:
10.1038/sj.npp.1300144
[Indexed for MEDLINE]
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