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Trends Biochem Sci. 2003 Jun;28(6):280-3.

A potential proteasome-interacting motif within the ubiquitin-like domain of parkin and other proteins.

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1
Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

Abstract

Parkin and other unrelated proteins contain a ubiquitin-like domain (UbLD). This article describes a motif that might be important in the interaction of UbLD-containing proteins (UbLPs) with the proteasome. The proteasome-interacting motif, which is conserved in a subset of UbLPs, such as parkin, Rad23 and several transcription factors, is likely to enable the UbLPs to form a complex with the proteasome for proteolysis or the recently discovered non-proteolytic functions of the proteasome.

PMID:
12826399
DOI:
10.1016/S0968-0004(03)00092-6
[Indexed for MEDLINE]
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