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Bioorg Med Chem Lett. 2003 Jul 21;13(14):2381-4.

Novel inhibitors of procollagen C-proteinase. Part 2: glutamic acid hydroxamates.

Author information

1
CombiChem Inc., 4570 Executive Drive, 92121, San Diego, CA, USA.

Abstract

Glutamic acid derived hydroxamates were identified as potent and selective inhibitors of procollagen C-proteinase, an essential enzyme for the processing of procollagens to fibrillar collagens. Such compounds have potential therapeutic application in the treatment of fibrosis.

PMID:
12824039
DOI:
10.1016/s0960-894x(03)00402-5
[Indexed for MEDLINE]

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