Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2003 Jul 21;13(14):2261-7.

Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles.

Author information

1
Lilly Research Laboratories, Eli Lilly and Company, 46285, Indianapolis, IN, USA. engler_thomas@lilly.com

Abstract

The synthesis and CDK inhibitory properties of a series of indolo[6,7-a]pyrrolo[3,4-c]carbazoles is reported. In addition to their potent CDK activity, the compounds display antiproliferative activity against two human cancer cell lines. These inhibitors also effect strong G1 arrest in these cell lines and inhibit Rb phosphorylation at Ser780 consistent with inhibition of cyclin D1/CDK4.

PMID:
12824014
DOI:
10.1016/s0960-894x(03)00461-x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center