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Trends Pharmacol Sci. 2003 Jun;24(6):263-6.

From nitric oxide to endothelial cytosolic Ca2+: a negative feedback control.

Author information

1
Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China. yao2068@cuhk.edu.hk

Abstract

Nitric oxide production is stimulated by an increase of the concentration of cytosolic Ca(2+) in vascular endothelial cells. Recent evidence suggests that nitric oxide and cGMP might attenuate Ca(2+) influx and, at the same time, initiate a Ca(2+) removal mechanism, thereby decreasing the intracellular concentration of endothelial Ca(2+) in a negative feedback fashion. Such a negative feedback mechanism could serve to protect the endothelial cells from the detrimental effects of excessive nitric oxide and Ca(2+).

PMID:
12823948
DOI:
10.1016/S0165-6147(03)00122-6
[Indexed for MEDLINE]

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