Send to

Choose Destination
Br J Haematol. 2003 Jul;122(1):94-8.

Expression profile of wild-type ETV6 in childhood acute leukaemia.

Author information

Children's Cancer Group, and Medical Oncology Unit, Cancer Research UK, St Bartholomew's and The London, Queen Mary School of Medicine and Dentistry, London, UK.


Comparative expression analysis of wild-typeETV6 in the disease state showed an absence of expression in ETV6-CBFA2 acute lymphoblastic leukaemia (ALL) when compared with non-ETV6-CBFA2 ALL and acute myeloid leukaemia. Fluorescent in-situ hybridization and loss of heterozygosity studies showed that 73% of the ETV6-CBFA2 samples had a fully or partially deleted second ETV6 allele, explaining the lack of wild-type expression in these patients. Although the second ETV6 allele was identified in the remaining patients, no ETV6 expression was detected. These observations support the hypothesis that loss of ETV6 expression is a critical secondary event for leukaemogenesis in ETV6-CBFA2 ALL.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center