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Acta Psychiatr Scand. 2003 Aug;108(2):144-6.

Neurological soft signs in never-treated schizophrenia.

Author information

1
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.

Abstract

OBJECTIVE:

Studies of Neurological Soft Signs (NSS) in schizophrenia are confounded by handedness, inconsistent methodology, and prior treatment with neuroleptics. The study objective is to examine NSS in never-treated schizophrenia.

METHOD:

We examined the NSS in treatment-naïve schizophrenia patients (n = 21) and age, sex, education, and handedness matched normal controls (n = 21) using the modified Neurological Evaluation Scale with good inter-rater reliability.

RESULTS:

Schizophrenia patients had significantly more NSS than normals. No significant correlation was found between illness duration and NSS.

CONCLUSION:

Higher neurological signs in never-treated patients and their lack of association with illness duration suggest neurodevelopmental etiopathogenesis of schizophrenia.

[Indexed for MEDLINE]

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