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Nat Prod Res. 2003 Aug;17(4):293-9.

Total synthesis of both enantiomers of the macrocyclic lactone citreofuran.

Author information

1
Department für Pharmazie--Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 München, Germany.

Abstract

Both enantiomers of the polyketide-derived lactone citreofuran (4) have been prepared. The enantiopure building blocks were obtained on a chemoenzymatic route ((S)-6) and by a chiral pool synthesis ((R)-6). The crucial step in the synthesis, a macrolactonization, was accomplished under Mitsunobu conditions.

PMID:
12822910
DOI:
10.1080/1478641031000137004
[Indexed for MEDLINE]

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