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Invest Radiol. 2003 Jul;38(7):423-7.

Comparison of multiple sclerosis lesions at 1.5 and 3.0 Tesla.

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Department of Neurology, Division of Brain Mapping, University of California Los Angeles, Los Angeles, CA, USA.



To evaluate the relative sensitivity of MR scanning for multiple sclerosis (MS) at 1.5 Tesla (T) and 3.0 T using identical acquisition conditions, as is typical of multicenter clinical trials.


Twenty-five subjects with MS were scanned at 1.5 T and 3.0 T using fast spin echo, and T(1)-weighted SPGR with and without gadolinium contrast injections. Image data, blinded to field strength, were analyzed using automated segmentation and lesion counting.


Relative to scanning at 1.5 T, the 3.0 T scans showed a 21% increase in the number of detected contrast enhancing lesions, a 30% increase in enhancing lesion volume and a 10% increase in total lesion volume.


The improved detection ability using high-field MR imaging is prominent even when sequence parameters are optimized around the midfield units. Multicenter trials using both 1.5 T and 3.0 T instruments may be affected by these sensitivity differences.

[Indexed for MEDLINE]

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