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Neurology. 2003 Jun 24;60(12):1995-7.

IV amantadine improves chorea in Huntington's disease: an acute randomized, controlled study.

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Department of Neuroscience, University of Pisa, Pisa, Italy.


The acute antidyskinetic effects of IV amantadine in HD were evaluated. A 2-hour IV infusion of amantadine or placebo was administered to nine patients with HD on two different days in a double-blind, randomized crossover fashion. All patients subsequently received oral amantadine unblinded for a 1-year period. A reduction of dyskinesia scores was reported during both IV and oral amantadine treatment (p < 0.05). No significant changes were observed in neuropsychological tests or psychiatric rating scales.

[Indexed for MEDLINE]

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