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Antimicrob Agents Chemother. 2003 Jul;47(7):2303-6.

Intracellular release of nitric oxide by NCX 972, an NO-releasing metronidazole, enhances in vitro killing of Entamoeba histolytica.

Author information

1
Laboratory of Parasitology, Istituto Superiore di Sanità, University of Rome "Roma Tre," Milan, Italy.

Abstract

The activity of NCX 972, a new molecule obtained by adding a nitric oxide (NO) moiety to metronidazole, was tested against six isolates of Entamoeba histolytica in xenic cultures. NCX 972 released NO into trophozoite cells and enhanced killing of amoebas in a dose- and time-dependent manner compared to metronidazole.

PMID:
12821483
PMCID:
PMC161880
[Indexed for MEDLINE]
Free PMC Article

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