Format

Send to

Choose Destination
See comment in PubMed Commons below
Zhonghua Liu Xing Bing Xue Za Zhi. 2003 May;24(5):389-92.

[A case-control study on the vitamin D receptor gene polymorphisms and susceptibility to pulmonary tuberculosis].

[Article in Chinese]

Author information

1
Epidemiological Department of Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.

Abstract

OBJECTIVE:

To investigate the association between the genetic polymorphisms of VDR gene and susceptibility to pulmonary tuberculosis.

METHODS:

Case-control study was conducted. PCR-RFLP technique was used to detect the C/T polymorphism in VDR gene. Information on related factors of tuberculosis was collected using a pre-tested questionnaire. Univariate and multivariate logistic analyses were conducted with SPSS software package.

RESULTS:

A sample of 76 cases and 171 controls was studied. The genotype frequencies of VDR-FF, VDR-Ff and VDR-ff were 38.2%, 44.7%, 17.1% and 52.6%, 40.9%, 6.4% respectively. VDR-ff was significantly overrepresented in case group, the OR (95% CI) was 3.668 (1.483 - 9.071) when comparing with FF genotype. The significant association remained after adjusting BCG immunization and smoking, the OR (95% CI) was 3.036 (1.117 - 8.253).

CONCLUSION:

The VDR-ff genotype might be associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.

PMID:
12820934
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center