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Biochim Biophys Acta. 2003 Jun 19;1627(2-3):85-9.

Identification of a glucocorticoid response element in the 3'-flanking region of the human Dexras1 gene.

Author information

1
Department of Anatomy, Physiology and Pharmacology, Auburn University, College of Veterinary Medicine, 213 Greene Hall, Auburn, AL 36849, USA. kempprj@vetmed.auburn.edu

Abstract

The Dexras1 gene responds to glucocorticoids with a rapid and profound induction. A glucocorticoid response element (GRE) was identified in the 3'-flanking region (2.3 kb downstream of poly(A) signal) of the human Dexras1 gene. This element conferred rapid glucocorticoid responsiveness when inserted into a homologous promoter-driven luciferase reporter. A point mutation within the 15-bp GRE abolished this glucocorticoid responsiveness.

PMID:
12818426
DOI:
10.1016/s0167-4781(03)00079-4
[Indexed for MEDLINE]

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