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Neuron. 2003 Jun 19;38(6):929-39.

Modulation of presynaptic store calcium induces release of glutamate and postsynaptic firing.

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1
Department of Physiology and Biophysics and The Neuroscience Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

Abstract

Action potential-independent transmitter release is random and produces small depolarizations in the postsynaptic neuron. This process is, therefore, not thought to play a significant role in impulse propagation across synapses. Here we show that calcium flux through presynaptic neuronal nicotinic receptors leads to mobilization of store calcium by calcium-induced calcium release. Recruitment of store calcium induces vesicular release of glutamate in a manner consistent with synchronization across multiple active zones in the CA3 region of the rat hippocampus. This modulation of action potential-independent release of glutamate is sufficient to drive the postsynaptic pyramidal cell above its firing threshold, thus providing a mechanism for impulse propagation.

PMID:
12818178
[Indexed for MEDLINE]
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