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Neuron. 2003 Jun 19;38(6):843-5.

From fragile X mental retardation protein to Rac1 GTPase: new insights from Fly CYFIP.

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1
Institut Cochin, INSERM unité 567, CNRS 8104, Université Paris V, CHU Cochin, 24 Rue du Faubourg Saint Jacques, 75014, Paris, France.

Abstract

Mutations in either the Rho GTPase pathway or in the fragile X mental retardation (FMR1) gene produce neuronal connectivity defects. In this issue of Neuron, Schenck et al. use biochemical and genetic approaches in Drosophila to examine the interactions between dFMR1 and dRac1 and provide evidence that the cytoplasmic FMRP interacting protein (CYFIP) links Rac-dependent cytoskeleton remodeling and dFMR1-dependent control of translation in a unique pathway to modulate neuronal morphogenesis.

PMID:
12818167
DOI:
10.1016/s0896-6273(03)00362-3
[Indexed for MEDLINE]
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