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FEBS Lett. 1992 Dec 21;314(3):386-8.

A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase.

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Department of Biochemistry, Faculty of Chemistry, University of Bielefeld, Germany.


Besides the monomeric mammalian 95 kDa progelatinase, two additional forms, a disulfide-bridged 220 kDa dimer and a 125 kDa form were isolated from human PMN leukocytes. The 125 kDa progelatinase was identified as a covalently linked, disulfide-bridged heterodimer formed of the monomer with a 25 kDa protein. This 25 kDa protein was isolated from gelatinase bound to the affinity support of gelatin-Sepharose and eluted by DTE-containing buffer. The amino acid sequence of tryptic peptides of this protein revealed homology with an alpha 2-microglobulin-related protein from rats, a protein so far unknown in humans.

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