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Org Lett. 2003 Jun 26;5(13):2211-3.

Formation of the dimethylbenzimidazole ligand of coenzyme B(12) under physiological conditions by a facile oxidative cascade.

Author information

1
Department of Bacteriology, University of Wisconsin, 1710 University Avenue, Madison, WI 53726-4087, USA.

Abstract

Dimethylbezimidazole, the axial ligand of vitamin B(12), is synthesized from riboflavin by a two-electron oxidation, a retro-aldol condensation, and a second two-electron oxidation. This oxidative cascade readily takes place nonenzymatically under physiological conditions. [reaction: see text].

PMID:
12816411
DOI:
10.1021/ol034530m
[Indexed for MEDLINE]

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