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Mol Biol (Mosk). 2003 May-Jun;37(3):556-60.

[Immunogenetic properties of peptides mimicking a human immunodeficiency virus gp41 (HIV-1) epitope recognized by virus-neutralizing antibody 2F5].

[Article in Russian]

Author information

1
Institute of Bioengineering, Vector State Research Center of Virology and Biotechnology, Kol'tsovo, Novosibirsk Oblast, 630559 Russia. tumanova_olga@mail.ru

Abstract

Phage display was used to obtain peptides mimicking a HIV-1 gp41 conserved epitope recognized by virus-neutralizing monoclonal antibodies (MCA) 2F5. Rabbits and mice were immunized with the peptides exposed on the surface of filamentous bacteriophages. Antibodies to gp41 were detected in the sera of immunized animals. The virus-neutralizing activity of the sera was examined.

PMID:
12815965
[Indexed for MEDLINE]

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