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Bioessays. 2003 Jul;25(7):691-8.

The pleiotropic functions of the Y-box-binding protein, YB-1.

Author information

1
Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.

Abstract

The Y-box-binding protein (YB-1) represents the most evolutionary conserved nucleic-acid-binding protein currently known. YB-1 is a member of the cold-shock domain (CSD) protein superfamily. It performs a wide variety of cellular functions, including transcriptional regulation, translational regulation, DNA repair, drug resistance and stress responses to extracellular signals. As a result, YB-1 expression is closely associated with cell proliferation. In this review, we will begin by briefly describing the characteristics of YB-1 and will then summarize the pleiotropic functions brought about via DNA-RNA transaction and protein-protein interactions. In addition, we will discuss the diverse range of potential physiological and pathological functions of YB-1.

PMID:
12815724
DOI:
10.1002/bies.10300
[Indexed for MEDLINE]

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