Format

Send to

Choose Destination
J Clin Epidemiol. 2003 May;56(5):395-407.

Defining clinically meaningful change in health-related quality of life.

Author information

1
Neuropsychiatric Research Institute, 700 First Avenue South, Fargo, ND 58107, USA. rcrosby@nrifargo.com <rcrosby@nrifargo.com>

Abstract

This article reviews current approaches to defining clinically meaningful change in health-related quality of life (HRQOL) and provides guidelines for their use. Definitions of clinically meaningful change are discussed. Two broad methods for identifying clinically meaningful change are contrasted: anchor-based methods and distribution-based methods. Anchor-based methods include cross-sectional approaches and longitudinal approaches. Distribution-based methods include those based on statistical significance, sample variability, and measurement precision. Anchor-based and distribution-based methods have advantages and limitations, and neither seems to be superior to the other. An integrated system for defining clinically meaningful change is recommended that combines anchor-based and distribution-based methods. We propose a new terminology for describing meaningful change derived from anchor-based and distribution-based methods.

PMID:
12812812
DOI:
10.1016/s0895-4356(03)00044-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center