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Dev Biol. 2003 Jul 1;259(1):95-108.

Zebrafish N-cadherin, encoded by the glass onion locus, plays an essential role in retinal patterning.

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1
Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA. jarema_malicki@meei.harvard.edu

Abstract

Genetic screens in zebrafish identified several loci that play essential roles in the patterning of retinal architecture. Here, we show that one of them, glass onion, encodes the N-cadherin gene. The glo(m117) mutant allele contains a substitution of the Trp2 residue known for its essential role in the adhesive properties of classic cadherins. Both the glo(m117) and pac(tm101b) mutant N-cadherin alleles affect the polarity of the retinal neuroepithelial sheet and, unexpectedly, both result in cell-nonautonomous phenotypes in retinal patterning. The late onset of mutant N-cadherin phenotypes may be due to the ability of classic cadherins to substitute each other's function.

PMID:
12812791
[Indexed for MEDLINE]
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