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Cancer Immunol Immunother. 2003 Oct;52(10):638-42. Epub 2003 Jun 14.

Enhanced expression of the complement regulatory protein CD55 predicts a poor prognosis in colorectal cancer patients.

Author information

1
CRC Academic Department of Clinical Oncology, City Hospital, Hucknall Road, NG5 1PB, Nottingham, Nottinghamshire, UK. lindy.durrant@nottingham.ac.uk

Abstract

This study prospectively correlated the level of expression of CD55 on tumours with 7-year survival in 136 colorectal cancer patients. Patients with tumours expressing high levels of CD55 had a significantly worse survival (24%) than patients with low CD55 levels (50%, p<0.02). A similar difference was seen for patients (Duke's B or C) with a high risk of recurrence (29% vs 58%, p<0.05). Furthermore, there was a progressive deterioration in prognosis with increasing antigen expression ( p=0.01). It remains unclear if CD55 is overexpressed by tumours to protect them from complement or if it is related to the recent observation that CD55 is a ligand for the T-cell activation antigen CD97. However, it is a marker of aggression, as colorectal cancer patients whose tumours overexpress CD55 have a significantly reduced 7-year survival.

PMID:
12811528
DOI:
10.1007/s00262-003-0402-y
[Indexed for MEDLINE]

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