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Cell. 2003 Jun 13;113(6):677-83.

PARP goes transcription.

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Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.


PARP-1, an enzyme that catalyzes the attachment of ADP ribose units to target proteins, plays at least two important roles in transcription regulation. First, PARP-1 modifies histones and creates an anionic poly(ADPribose) matrix that binds histones, thereby promoting the decondensation of higher-order chromatin structures. Second, PARP-1 acts as a component of enhancer/promoter regulatory complexes. Recent studies have shown that both of these activities are critical for gene regulation in vivo.

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