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Ann Intern Med. 2003 Jun 17;138(12):969-73.

Long-term effects of inhaled corticosteroids on FEV1 in patients with chronic obstructive pulmonary disease. A meta-analysis.

Author information

1
Division of Pulmonary, Critical Care, Allergy and Clinical Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, 812 CSB, Box 250623, Charleston, South Carolina 29425, USA. highlakb@musc.edu

Erratum in

  • Ann Intern Med. 2003 Nov 18;139(10):873.

Abstract

BACKGROUND:

There is no consensus on the effectiveness of inhaled corticosteroids for the treatment of chronic obstructive pulmonary disease (COPD).

PURPOSE:

To evaluate the long-term effects of inhaled corticosteroids on the rate of FEV1 decline in patients with COPD.

DATA SOURCES:

MEDLINE, EMBASE, CISCOM, and AMED databases and the Cochrane Library (1966 to December 2002), reference lists from identified articles, and consultation with experts. Searches were not limited to the English language.

STUDY SELECTION:

Randomized, placebo-controlled trials that examined the rate of FEV1 decline as a primary outcome in patients with COPD.

DATA EXTRACTION:

Two reviewers independently extracted the data by using predetermined criteria.

DATA SYNTHESIS:

For the six studies that met the inclusion criteria, the summary estimate for the difference in FEV1 decline between the placebo and treatment groups was -5.0 +/- 3.2 mL/y (95% CI, -11.2 to 1.2 mL/y; P = 0.11).

CONCLUSIONS:

The use of inhaled corticosteroids was not associated with the rate of FEV1 decline in 3571 patients followed for 24 to 54 months.

[Indexed for MEDLINE]

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