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Arch Phys Med Rehabil. 2003 Jun;84(6):825-7.

Overwork weakness in Charcot-Marie-Tooth disease.

Author information

  • 1Department of Rehabilitation of Charcot-Marie-Tooth Disease and Other Neuromuscular Disorders, Specialized Rehabilitation Hospital L. Spolverini, Ariccia, Rome, Italy. paolovinci@libero.it

Abstract

OBJECTIVE:

To determine the incidence of overwork weakness in Charcot-Marie-Tooth disease (CMT).

DESIGN:

Prospective survey.

SETTING:

Rehabilitation department for CMT in an Italian tertiary care hospital.

PARTICIPANTS:

A total of 106 outpatients with CMT, selected for absence of other causes of weakness (age range, 11-69y), and 48 healthy volunteers (controls).

INTERVENTIONS:

The strength of 2 intrinsic hand muscles (abductor pollicis brevis [APB], first dorsal interosseous) in the dominant and nondominant hands was graded by using manual muscle testing and a modified Medical Research Council (MRC) Scale.

MAIN OUTCOME MEASURES:

The side of the stronger muscle and the difference in strength between the nondominant and dominant muscles.

RESULTS:

Muscles were stronger on the nondominant side in 65.57% of patients versus 1.04% of controls, and on the dominant side in .94% of patients versus 84.38% controls. The difference in strength for first dorsal interosseous was .51 in patients and -.32 in controls (P>.01). The difference in strength for APB was .65 in patients and -.35 in controls (P>.01).

CONCLUSIONS:

CMT muscles in the dominant hand are weaker than in the nondominant hand. This may be the result of overwork weakness.

PMID:
12808533
[PubMed - indexed for MEDLINE]
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