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Pain. 1992 Sep;50(3):317-21.

An effect of ascorbic acid on delayed-onset muscle soreness.

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Division of Basic Sciences, Western States Chiropractic College, Portland, OR 97230.


Delayed-onset muscle soreness following strenuous use of the posterior calf muscles was studied to determine if ascorbic acid might have an effect on the appearance of this familiar pain. A double-blind, randomized, crossover study compared the soreness in subjects taking ascorbic acid against those taking a lactose placebo. Visual analog scales were used in conjunction with a variety of pain-challenging methods, and the results indicated a significant difference between experimental and placebo groups at the height of soreness. Typical soreness abatement scores of 25-44% were observed. A sample size of 19, lack of an untreated control group as well as the singular nature of the exercise and its intensity were considered limitations of the study.

[Indexed for MEDLINE]

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