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Mol Cells. 2003 Apr 30;15(2):164-75.

Telomeres and telomerase in aging, regeneration and cancer.

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  • 1Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover Carl-Neuberg-Str. 1 30625 Hannover, Germany.

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  • Mol Cells. 2003 Aug 31;16(1):142.

Abstract

The finding that telomere shortening limits the replicative lifespan of primary human cells has fueled speculations that telomere shortening plays a role during aging and regeneration of tissues in vivo. Support for this hypothesis comes from studies showing telomere shortening in a variety of human tissues as a consequence of aging and chronic disease. Studies in telomerase-deficient mice have given first experimental support that telomere shortening limits the replicative potential of organs and tissues in vivo and have identified telomerase as a promising target to treat regenerative disorders induced by telomere shortening. A potential downside of such an approach could be the development of malignant tumors, which has been linked to reactivation of telomerase in human cancers. In telomerase-deficient mice, telomere shortening showed a dual role in tumorigenesis, enhancing the initiation of tumors by induction of chromosomal instability but inhibiting tumor progression by induction of DNA-damage responses. The success in using telomerase activation for the treatment of regenerative disorders could depend on which of the mechanisms of telomere shortening is dominantly effecting carcinogenesis.

PMID:
12803478
[PubMed - indexed for MEDLINE]
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