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Gut. 2003 Jul;52(7):918-21.

Gut and mind.

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  • 1Department of Metabolic Medicine, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.


Obesity is a growing epidemic, causally associated with a number of serious medical conditions, including diabetes mellitus, coronary heart disease, and several cancers. The gut hormones ghrelin and peptide YY are secreted from the gut in response to changes to nutritional status. While food intake is stimulated by ghrelin, it is inhibited by peptide YY. The discovery, anatomy, and physiology of ghrelin and peptide YY are discussed, focusing on the adaptive changes in diseases such as obesity and anorexia nervosa. Ghrelin and PYY are important therapeutic targets in the quest to find an effective antiobesity treatment.

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