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Trends Genet. 2003 Jun;19(6):321-9.

The diverse functions of histone acetyltransferase complexes.

Author information

1
Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Penn State University, University Park, PA 16803, USA. mjc28@psu.edu

Abstract

Although histone acetylation has historically been linked to transcription activation, recent studies indicate that this modification and the enzymes that catalyze it have much broader and diverse functions. Histone acetyltransferase complexes are involved in such diverse processes as transcription activation, gene silencing, DNA repair and cell-cycle progression. The high conservation of the acetyltransferase complexes and their functions illustrates their central role in cell growth and development.

PMID:
12801725
DOI:
10.1016/S0168-9525(03)00115-X
[Indexed for MEDLINE]

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