Format

Send to

Choose Destination
See comment in PubMed Commons below
Gene. 2003 May 22;310:169-73.

Molecular cloning of the pawn locus from Drosophila melanogaster.

Author information

1
Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA.

Abstract

Alleles of pawn have numerous morphological phenotypes, including dark deposits on the eye, truncated bristles, and semilethality. The gene encoding the pawn locus was cloned. The Pawn protein is predicted to be a large cell adhesion molecule with a single transmembrane domain, a short cytoplasmic tail and two extracellular epidermal growth factor (EGF)-like repeats. The identity of the pawn gene product was confirmed by sequencing the defects in four different pawn alleles. Analysis of cDNAs showed a complex genomic structure with two 5' untranslated exons and developmental-specific RNA splicing. The gene is expressed throughout development with highest expression found in the late embryonic and larval stages.

PMID:
12801644
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center