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Biochem Biophys Res Commun. 1992 Oct 30;188(2):760-6.

The glycoprotease of Pasteurella haemolytica A1 eliminates binding of myeloid cells to P-selectin but not to E-selectin.

Author information

1
Monsanto Corporate Research, Monsanto Company, St. Louis, MO 63167.

Abstract

HL-60 cells and neutrophils treated with the glycoprotease from Pasteurella haemolytica A1, an enzyme which is specific for O-sialoglycoproteins, were found to be incapable of binding P-selectin but still bound E-selectin. Comparative analysis of [35-S] cysteine labeled proteins from HL-60 cells by 2-dimensional electrophoresis indicated that two major proteins with M(r) 100 and 115 kd were significantly removed from cells which had been treated.

PMID:
1280121
DOI:
10.1016/0006-291x(92)91121-6
[Indexed for MEDLINE]

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