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Pyruvate kinase: current status of regulatory and functional properties.

Author information

1
Facultad de Ciencias Quíicas e Ingenierí, Universidad Autónoma de Baja California, Av. Tecnológico s/n, Mesa de Otay, B.C., Tijuana, Mexico C.P. 22390.

Abstract

Pyruvate kinase (PK) is a key enzyme for the glycolytic pathway and carbon metabolism in general. On the basis of the relevance and enormous diverse properties of this enzyme, this paper describes the results of a current and extensive review that determines the sites of conservation and/or difference in PK sequences, and the differences in the functional and regulatory properties of the enzymes. An alignment and analysis of 50 PK sequences from different sources and a phylogenetic tree are presented. This analysis was performed with reference to crystallographically characterized PK principally from E. coli, cat and rabbit muscle. A number of attributes of the enzyme that make it of particular interest in biomedicine and industry are also discussed.

PMID:
12798932
DOI:
10.1016/s1096-4959(03)00081-2
[Indexed for MEDLINE]

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