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Fertil Steril. 2003 Jun;79(6):1294-8.

Poor response after hormonal stimulation for in vitro fertilization is not related to ovarian aging.

Author information

1
Infertility Center, Department of Gynaecology and Obstetrics, University Hospital Ghent, Ghent, Belgium. paul.desutter@rug.ac.be

Abstract

OBJECTIVE:

To investigate whether the diminished efficacy of ART in young poor responders compared to young normal responders is due to a quantitative or a qualitative oocyte factor.

DESIGN:

Retrospective comparative analysis.

SETTING:

University-based infertility center.

PATIENT(S):

Nine thousand six hundred forty-four patients who underwent ART procedures at our hospital from 1993 until 2001.

INTERVENTION(S):

Controlled ovarian hyperstimulation, ultrasonographic monitoring of the ovarian response, oocyte retrieval, ART procedure, embryo transfer, and follow-up of pregnant patients until 12 weeks of amenorrhea.

MAIN OUTCOME MEASURES:

Clinical rates of pregnancy and miscarriage.

RESULT(S):

Nine thousand six hundred forty-four ART cycles were analyzed. The pregnancy rate for poor responders was significantly lower than for normal responders (17% vs. 35%). In cycles in which two good-quality embryos were transferred, the pregnancy rate was similar in poor responders and normal responders (33% vs. 42%). The rate of miscarriage was no higher in poor responders than normal responders.

CONCLUSION(S):

Young poor responders have a lower pregnancy rate than young normal responders because they have fewer oocytes, which leads to fewer good-quality embryos to choose from for transfer. The quality of their oocytes and embryos is not inferior to that of normal responders.

PMID:
12798873
[Indexed for MEDLINE]
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